Response of the cardiovascular system of cats to ansamycins in the test for depressor substances

Response of the cardiovascular system of cats to ansamycins in the test for depressor substances

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The article summarises the results of a study which assessed the response of the click here cardiovascular system of cats to intravenous administration of the ansamycin class of antibiotics using commercial samples and investigational samples of rifampicin and rifabutin for injections.It was shown that intravenous administration of ansamycin solutions was accompanied by hypotensive effects of varying severity.The increase in the rate of rifampicin administration at a dose of 2.0 mg/0.5 ml/kg can result in a greater decrease of the cat’s blood pressure as compared to the effect caused by the administration of the same dose at a here rate described in the monograph 1.

2.4.0008.15 «Test for depressor substances».Based on the results of the study a mechanism underlying the observed effect was suggested.